The frequency of the recessive allele for the Hbs gene when there is an outbreak of malaria will increase.
The sickle hemoglobin is produced by the HbS gene, a variation of the B-globin gene. A person who possesses two recessive alleles is said to have the genetic condition known as sickle cell anemia.
People who are heterozygous have the advantage of having normal and sickle hemoglobin, so they are more resistant to malaria because malaria will only act on normal hemoglobin, increasing the prevalence of the recessive allele of the HbS gene.
However, the malarial parasite only affects hemoglobin which is normal, making heterozygous people more resistant to the disease. Hence, the frequency of the recessive allele for the Hbs gene when there is an outbreak of malaria will increase.
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