When patient has hypothyroidism and therefore his na /k atpase pumps are functioning at a reduced rate. Then there will be a reduction in Na+ transport in Bowman's capsule epithelial cells.
It happens due to hypothyroidism which reduced renal plasma flow, and low glomerular filtration rate (GFR) of nephron. glomerular filtration takes place in bowmans capsule epithelial cells of nephron which results in the reduction of sodium transport in epithelial cells of Bowman's capsule.
Hypothyroidism (underactive thyroid) is a condition in which your thyroid gland doesn't produce enough of certain crucial hormones.
Hypothyroidism may not cause noticeable symptoms in the early stages. Over time, untreated hypothyroidism can cause a number of health problems, such as obesity, joint pain, infertility and heart disease.
Symptoms
The signs and symptoms of hypothyroidism vary, depending on the severity of the hormone deficiency. Problems tend to develop slowly, often over a number of years.
At first, you may barely notice the symptoms of hypothyroidism, such as fatigue and weight gain. Or you may simply attribute them to getting older. But as your metabolism continues to slow, you may develop more-obvious problems.
Hypothyroidism signs and symptoms may include:
- Fatigue
- Increased sensitivity to cold
- Constipation
- Dry skin
- Weight gain
- Puffy face
- Hoarseness
- Muscle weakness
- Elevated blood cholesterol level
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