Question

nutrient stream (containing no penicillin) is fed to a 10 L reactor containing the Penicillium chrysogenum bacteria. A product stream is containing penicillin leaves the reactor (the bacteria stay in the reactor, and the penicillin concentration in the product stream is the same as inside the reactor). The densities of the nutrient and product streams can be assumed to be equal. What is the production rate of penicillin under these conditions

Answer 1

The method utilised to produce penicillin for use in medicine is fermentation. It is a fed-batch procedure done aseptically in stainless steel tank reactors with a 30–100,000 gallon capacity.

What is fermentation in a chemostat?

The chemostat is a continuous stirred tank reactor in which a straightforward continuous process occurs as a steady-state process without the recycling of settled sludge and with an influent devoid of microorganisms. Bacterial growth is started through injection.

What distinguishes a turbidostat from a chemostat?

The volume and flow rate of a chemostat are fixed, and therefore is the dilution rate. To maintain a consistent turbidity, a turbidostat dynamically modifies the flow rate (and consequently the dilution rate). Both the turbidostat and the chemostat operate indistinguishably in steady state.

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