Question

Onsidering that gluconeogenesis requires a net input of 4 atp equivalents compared to glycolysis, why would a cell utilize this pathway, ie., what is the metabolic advantage of this pathway?

Answer 1

The process by which organisms create sugars (specifically glucose) from non-carbohydrate precursors is known as gluconeogenesis.

• The only energy source used by the brain, testes, erythrocytes, and renal medulla is glucose, with the exception of ketone bodies during fasting. There are three highly exergonic stages in glycolysis. Hexokinase, phosphofructokinase, and pyruvate kinase are among the enzymes involved in these additional regulatory stages. In biological processes, both forward and backward reactions are possible.
• Similar to glycolysis, but with the process going the other way, is gluconeogenesis. Fructose-1,6-bP, glucose-6-P, and pyruvate all undergo fairly spontaneous conversions in the process of gluconeogenesis, which is why these reactions are tightly controlled.
• For the organism to function properly, energy conservation is crucial. Gluconeogenesis is suppressed when there is an abundance of energy available.

Therefore, gluconeogenesis conserve more energy.

Learn more about gluconeogenesis:

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