If a cell is no longer able to differentiate into any type of tissue, it has become a differentiated cell.
A stem cell can differentiate into a different kind through cellular differentiation. Usually, the cell will transform into a new, more specialized type. As a multicellular organism develops from a simple zygote to a complex system of tissues and cell types, it passes through multiple differentiation cycles. Adult stem cells continue to grow when they divide into fully differentiated daughter cells during tissue repair and regular cell turnover. Immune reactions to an antigen lead to differentiation. A cell's size, shape, membrane potential, metabolic activity, and signal receptivity all vary dramatically during differentiation.
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