A. Immune system
It helps our bodies fight everything that comes in our path.
Polypeptide chains undergo some modifications before they become fully functional. Some of these modifications include: proteolytic cleavage, lipidation and glycosylation. Proteolytic cleavage refers to the removal of some amino acids from a polypeptide chain by proteases in order for the protein to become active. An example of a substance that is modified through this process is insulin.
<h3><u>Answer;</u></h3>
Gene therapy to correct defective genes that cause diseases.
<h3><u>Explanation</u>;</h3>
- Gene therapy refers to the procedure that involves the introduction of nucleic acids (DNA or RNA) into the cells of an organism for the purpose of correcting abnormalities, such as a mutations or in other words to treat a genetic disease.
- Gene therapy entails bringing a normal and functional gene known as a trans-gene into a cell with altered gene. Another method can bring RNA capable of partially regulating or blocking the expression of an altered gene.
- The nucleic acids are introduced into the patient's cells by means of a viral vector or injected directly into the cells in the form of naked DNA.
Answer: A federally funded research study involving children 8 to 12 years old involves collecting a single voided urine sample to assess the frequency of asymptomatic <em>proteinuria</em>.
Your IRB has determined that assent of children age 8 and older is required for the study. A 10 year old firmly declined to participate in the study.
The best procedure that describes the <u>action </u>to be taken by the investigator is:
- Honor the Childs decision .
Explanation:
The <em>purpose</em> of the IRB is to <em>assure that appropriate steps are taken</em> to <em>protect the rights </em>and welfare of humans participating as subjects in a research study. It promotes <em>fully informed and voluntary participation</em> by prospective subjects capable of making such choices (or, if that is not possible, informed permission given by a suitable proxy), and seeks to maximize the safety of subjects.
The capacity admits degrees. The same patient may be able to decide certain things and not others. So, the more transcendent or delicate a decision is, the higher the level of capacity required must be. When the patient <u>is not capable, it is up to his relatives to make the decisions.</u>
