Question

What structure allows the hypothalamus to have direct communication with the anterior pituitary?

Answer 1

Hypophyseal portal system allows the hypothalamus to have direct communication with the anterior pituitary.

The hypophyseal portal system is a network of blood vessels that connects the anterior portion of the gland and hypothalamus at the base of the brain. Two capillary beds, one in the median eminence and the other in the anterior pituitary, make up the portal system. Its principal job is to swiftly transfer and exchange hormones between the anterior pituitary gland and the hypothalamic arcuate nucleus.

The cortisol, androgens, and aldosterone hormones interact with anterior pituitary gland cells via travelling through the hypophyseal portal system. Hormonal signaling through the hypophyseal portal system enables connection between these two structures.

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