The answer is hydrogen bond.
Between water molecules, hydrogen bonds can be seen, which is due to the polar nature of water.
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Gradual changes in the frequency of diseases over long periods are known as SECULAR TIME TRENDS. For example, the rate of mortality in USA due to coronary heart diseases over a period of time. Onset of puberty in girls is also a secular time trend.
Secular time trend is also referred as Secular Variation and Secular Drift.