Answer:
Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney and liver function among United States (U.S.) adolescents. This study aimed to evaluate whether greater fluoride exposure is associated with altered kidney and liver parameters among U.S. youth.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2013–2016). We analyzed data from 1983 and 1742 adolescents who had plasma and water fluoride measures respectively and did not have kidney disease. Fluoride was measured in plasma and household tap water. Kidney parameters included estimated glomerular filtration rate (calculated by the original Schwartz formula), serum uric acid, and the urinary albumin to creatinine ratio. Liver parameters were assessed in serum and included alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, gamma-glutamyl transferase, and albumin. Survey-weighted linear regression examined relationships between fluoride exposure and kidney and liver parameters after covariate adjustment. A Holm-Bonferroni correction accounted for multiple comparisons.
The average age of adolescents was 15.4 years. Median water and plasma fluoride concentrations were 0.48 mg/L and 0.33 μmol/L respectively. A 1 μmol/L increase in plasma fluoride was associated with a 10.36 mL/min/1.73 m2 lower estimated glomerular filtration rate (95% CI: −17.50, −3.22; p = 0.05), a 0.29 mg/dL higher serum uric acid concentration (95% CI: 0.09, 0.50; p = 0.05), and a 1.29 mg/dL lower blood urea nitrogen concentration (95%CI: −1.87, −0.70; p < 0.001). A 1 mg/L increase in water fluoride was associated with a 0.93 mg/dL lower blood urea nitrogen concentration (95% CI: −1.44, −0.42; p = 0.007).
Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents. As the study is cross-sectional, reverse causality cannot be ruled out; therefore, altered kidney and/or liver function may impact bodily fluoride absorption and metabolic processes.
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Answer:
A hypertonic solution
Explanation:
There is a greater concentration of solutes outside of the cell than there is inside the cell, therefore it will rush out.
<span>The technique that uses the images from several telescopes to produce a single image is called 'Astronomical interferometery. By combining images from several telescopes, it is possible for astronomers to create detailed images with high resolutions. </span>
to classify it as a protostome, zoologist must see for the mouth development in the embryo.
Explanation:
The protostome are the animals which are unique to their three germ layer in embryonic development, with the bilateral symmetry as they have the ability to fly with other protostome developments.
the one characteristic feature to distinguish them as the protostome, mouth part development is to be sought as the mouth develops but not the anus in the embryo. the mouth parts serves unique to the group and their feeding structures.
First answer is correct. Eutrophication can have serious effects, like algal blooms that block light from getting into the water and harm the plants and animals that need it. If there's enough overgrowth of algae, it can prevent oxygen from getting into the water, making it hypoxic and creating a dead zone where no organisms can survive.