They both are encased organelle compartments inside a cell but A vacuole is the vesicle found within a cytoplasm of a cell. The vacuole contains some fluid. A lysosome, on the other hand, is an organelle found within the cytoplasm of eukaryotic cells.
Lysosomes and vacuoles both deal with waste materials. Lysosomes break down waste materials, and vacuoles store waste materials in the cell temporarily before the cell get rids of them.
The pancreas detects that the blood sugar level is higher and releases insulin. It tells the liver to store glucose in the blood as glycogen. This regulates the blood sugar levels