Question

Which of the following effects is least likely to be mediated by a scaffolding protein ? Increase the local concentration of signaling components. Decrease allosteric effects and cooperative binding of second messengers to their targets. Regulate the order in which a series of kinases can become activated following receipt of a signal. Decrease likelihood of crosstalk between signaling pathways that share a common kinase. Allow rapid negative feedback of a signaling response.

Answer 1

The correct answer is: Decrease allosteric effects and cooperative binding of second messengers to their targets.

Scaffold proteins are considered regulatory proteins that affect many signal pathways. Some of their functions are:

• Regulation and coordination of positive and negative feedback signals

• Localizing signal components within the cell (in different cell compartments)

• Tethering signaling components (assembling signal components into complexes in order to increase signal efficiency).