Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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Answer:
It is a beneficial mutation.
Explanation: Mutations are permanent changes in the nucleotide sequence of a DNA. Mutations can beneficial, neutral and harmful or deleterious. When change in the nucleotide sequence of DNA a mutation enhances the effectiveness of a protein or improves the protein function, it is said to be beneficial. When a mutation causes the synthesis of a protein which have the same amino acid as the original protein and performs the same function as the original protein, it is said to be silent or neutral. When a mutation results in the synthesis of a protein with an altered amino acid sequence and a nonfunctional protein, it is said to be harmful.
Answer:
Crossing over is termed as a process by which genetic materials are exchanged by non-sister chromatids during meiosis. Crossing over results in the new combination of information in genetic for, the cell for a specific trait. It ensures that organisms are identical from one generation to another.
Explanation:
Answer is: when the carbon atoms of the glucose molecule are broken apart in glycolysis and the Krebs cycle, result is a. CO2 and ATP.
In Krebs cycle aerobic organisms release stored energy through the oxidation of acetyl-CoA derived from glucose into carbon dioxide and chemical energy in the form of adenosine triphosphate (ATP).
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Explanation:
Where Translation Occurs. Within all cells, the translation machinery resides within a specialized organelle called the ribosome. In eukaryotes, mature mRNA molecules must leave the nucleus and travel to the cytoplasm, where the ribosomes are located.
