Hamilton was heavily in favor of trading with Great Britain, but the Republicans were against it, arguing that it would reduce Americans' liberty. Therefore the biggest probably facing trade was political opposition.
Alexander Hamilton created a system of tariffs, and excise taxes into effect to help pay down the national debt accrued during the Revolutionary war. The excise taxes eventually led to the Whiskey Rebellion.
In this political cartoon, the author shows Uncle Sam standing on top of the world. This represents how much power that the America received from the Monroe Doctrine and shows their status in relation to the rest of the world.