There are as many palindromic 12-bit binary strings as there are permutations with repetition of 6-bit binary strings, which is equal to .
There are also only two permutations with repetition of 6-bit binary strings, that when each of them is mirrored and the result is "glued" to the right side of the original string, will give a palindromic string without 10 as a substring. Those strings are 000000 and 111111.
Therefore there are palindromic 12-bit binary strings with 10 as substring.