If you are talking about the development of political parties, then the issue that led it to them was “the struggle over ratification of the federal Constitution of 1787” (loc.gov).
Federalists, such as Alexander Hamilton, wanted a strong, central government and the Anti-Federalists, like Thomas Jefferson, “advocated states’ rights instead of centralized power”. (Library of Congress)
Making medicine impacted the Gupta Empire because there were less deaths, more ways to cure people of disease. It helped with the birth rates too, since usually back then alot of women died during labor.
Expend money with the expectation of achieving a profit or material result by putting it into financial schemes, shares, or property, or by using it to develop a commercial venture.
