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Nondisjunction results when chromosomes in gametes (egg and sperm cells) do not separate properly during meiosis (cell division of gametes in 2 stages), producing gametes which have more or less than the normal number (23) of chromosomes.
Nondisjunction occurs during anaphase of either Meiosis I or Meiosis II. Anaphase is the splitting and pulling of the chromosomes, lined up at the center of the cell, to the edges or poles of the cell. Shown in the figures below are examples of when nondisjunction occurs in Meiosis I (Anaphse I) and in Meiosis II (Anaphase II).
(Figures source: http://study.com/academy/lesson/nondisjunction-in-meiosis-definition-examples-quiz.html)
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