Ciprofloxacin inhibits DNA gyrase, a bacterial topoisomerase that cuts DNA ahead of the replication fork, winds the DNA in a dir
ection that relieves the twists added during DNA synthesis, and then reseals the DNA. In ciprofloxacin-treated bacteria, newly synthesized DNA is found in fragments. Based on this evidence, what activity of DNA gyrase is likely to be inhibited by ciprofloxacin? ligase activity. DNA polymerase activity. primase activity. helicase activity
This is because ligase has the role to connect DNA fragments.
DNA gyrase is one of the enzymes involved in prokaryotic DNA replication. It introduces negative supercoils into DNA and for this process ATP is required. This enables the process of replication to continue.
