Answer and Explanation:
1. Amino-acid sequence is the primary structure of a protein
2. Alpha helices, beta sheets and coiled coils refers to the protein folding and they represent the secondary structure of a protein
3. Protein ensemble formed by alpha helices, beta sheets and coiled coils represent the tertiary structure of a protein
4. Macromolecules with multiple polypeptides form globular or fibrous protein structures (quaternary structure)
Mutation is the only evolutionary mechanism that does little to change allele frequencies.
