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The arrival of Europeans in the Americas led to the conquest of the Incan and Aztec empires.
One advantage the Spanish had in their conflict with the Aztec and Inca was their weaponry.
The Spanish wanted to conquer early American civilizations to gain power over other European nations
After the Spanish arrived in the Americas, the Aztec and Inca were weakened by the spread of disease.
We are talking about the times of the conquering of the two most important civilizations in pre-Hispanic times: the Aztec Empire in Mesoamerica and teh Inca Empire in South America.
The Aztecs thought that the Spaniards were their gods, according to their ancestors' prophecy that referred to the return of Quetzalcoatl, their most important god. That is why the Aztecs welcomed the Spaniards with open hands.
The Spanish had better weapons, fire weapons, and convinced the Aztec's enemies to unite and fight for retribution.
In both cases, Aztecs and Incas suffered from the series of diseases that Spaniards brought to the Americas. We are talking about malaria, cholera, chickenpox, smallpox, and influenza.