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aliina [53]
3 years ago
13

(USATP)

Biology
1 answer:
kobusy [5.1K]3 years ago
7 0

Answer:

its a

Explanation:

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ATM activated by MRN complex at the site of DNA double stranded breaks by phosphorylation. MRN complex activity on ATM induces a conformational change in ATM kinase. So it can bind to its various substrate molecules that helps in DNA replication cycle arrest.

ATM phosphorylates CHK2 protein a product of CHEK2 gene, also known as effector kinases that phosphorylates and helps in deactivation of cyclin dependent kinases (CDKs) that helps in the prevention of progression of mitotic phase.

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