True that should be the answer
Induced depression of single neurons in brain areas with opiate receptors
- Enkephalin, applied microiontophoretically, depressed spontaneous and glutamate-induced firing of one neuron in frontal cortex, caudate nucleus, and periaqueductal gray matter, where enkephalin and high concentrations of opiate receptors are met.
- More than one depressions were blocked by the specific narcotic antagonist naloxone. The results are durable with a neurotransmitter or neuromodulator role for this new brain pentapeptide.
- Opium derivatives have been in medical use for the last 2000 years, and may be longer than any other class of drugs
- . The brain regions which was involved in these actions have been identified in some instances by local microinjection of pmole quantities of opioids.
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Answer:
Blood Brain Barrier(BBB)
Explanation:
This is a biological interface of special endothelial cells of astrocytes, pericytes , capillaries, neurons and other structures, acting as a physical barrier or gate separating the Central Nervous system from the peripheral blood circulations. Thus it formed a tight junction serving as a physical barrier to selectively regulate the entrance of substances from the cerebral blood flow into the brain, therefore maintaining homeostasis of the brain.
From above any substances absorbed into the blood stream irrespective of the mode of entry are transported through the BBB, and are selectively regulated to enter the brain cells by the BBB's interactions with the blood vessels, hormones etc.
Basically it allows the passage of nutrients, a few drug, hormones and resists certain toxins and pathogens for the brain homeostasis.
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