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Tanzania [10]
3 years ago
5

The rate of firing of the postsynaptic neuron depends on the amount of _____ input it receives from the presynaptic neuron.​

Biology
1 answer:
jonny [76]3 years ago
8 0
<span>both excitation and inhibition</span>
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G protein‑coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) are two basic receptor types by which cells transduce s
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<h2>GPCRs and RTKs</h2>

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1) Phosphorylation of receptor can terminate signal or desensitize receptor: GPCRs because when signal persists a protein kinase receptor is activated,this further catalyse the phosphorylation of several serine residue at cytosolic phase of 7 transmembrane

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3) Structure contains seven transmembrane helices: GPCRs because it consists of single polypeptide and spans the membrane 7 times hence called 7 transmembrane;it recognizes external signal and activates trimeric G protein

4) Ligand binding induces conformational change in receptor: RTKs because normally RTK exist in monomeric form in absence of any ligand molecule but when any ligand molecule binds receptor starts to dimerize

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6) An example is the insulin receptor: Insulin receptor is present on plasma membrane and belongs to RTK family and always exist in dimeric form

7) Transports some ligands through the membrane: Neither GPCR nor RTK;ligand gets transported through the membrane through ligand gated channel

8) An example is the epinephrine receptor: Epinephrine is an endocrine  hormone produced by adrenal glands in stress condition and prepare body for fight and flight;Epinephrine uses GPCR signalling pathway by four different types of membrane receptors in different tissues

9) Activate heterotrimeric G proteins directly: Transmembrane protein of GPCR recognizes the external signal and activates G protein,activated G protein binds with effector enzyme and activate it which further produce or destroy secondary messenger that carry message from cell surface to cell interior

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Hop you have a great day :)

Explanation:

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