Irony is a discrepancy or an incongruence between what is anticipated and to what it actually is. There are three types of irony. One would be verbal irony which, as the name suggests, revolves around speaking or what is said. The other two would be dramatic irony and situation irony. Dramatic irony is usually used in plays, dramas, and the like that involves the audience's awareness. Situation irony would be more involved with what's happening around.
Macbeth, Lady Macbeth and the three witches are all to blame for the tragedy that is “Macbeth”, Lady Macbeth through convincing Macbeth, Macbeth for following his ambition more than his conscience and the three witches for putting the idea of being king in Macbeth's head.