Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Bacteria are the plural of bacterium, which are microscopic one-celled organisms. They are found everywhere and can be harmful, as in infections; or they can be beneficial, as in fermentation or decomposition. Five types of bacteria are: Coccus, Bacillus, Spirillum, Rickettsia, and Mycoplasma.
Unbalanced,
Na + Cl2
Na = 1
Cl = 2
NaCl
Na = 1
Cl = 1
Basically, both the reactants and products must have equal amounts of each element.
Yes, protists have cell walls.
Protists cell walls are made of composed cellulose, protein strips , and silica
For some protists, we can even found components like pectin on the cell walls
hope this helps
Variation and natural selection
