Travel thru the other cells
Substitution mutation is when a single base pair in a strand of DNA is replaced. This can cause an early stop amino acid, or the protein could change slightly, or the protein could be unchanged completely due to there being multiple base pairs to make an amino acid.
Most mutations have no effect on organisms. Organisms all have large amounts of genetic code, most of which has no effect. As a result, mutation of this code is rarely meaningful.
I believe the answer is the global free-market approach.
It is because on continually increasing use of earth's natural capital, and it focuses on short term economic benefits with little regard for degradation and depletion of natural capital and resulting long-term harmful environmental, health, and social consequences. Environmental world views are the ways of thinking about how the world work and beliefs that people hold about their roles in the natural world, another factor is widespread lack of understanding of how earth's life-support system works, keeps us alive, and supports economies.