Substances can move from areas of low concentration to high concentration.
Explanation:
For the first one, substances CAN move in and out of cells in an active transport.
As for the second one, active transports do require energy. That is what makes them "active" and sets them apart from <em>passive transports</em> which don't require energy.
Lastly, substances can move across a membrane regardless of if they are water soluble (such as lipids, or fats that the cell does not use. Think of it as a way for the cell to eat, drink, and defecate or remove waste.)
