Answer:
B) Hypogranular neutrophils
Explanation:
Myelodysplastic syndrome occurs due to a disordered production of blood cells in the bone marrow that die before they are even released into the bloodstream. This syndrome is of great clinical significance as they may progress to Acute Myeloid Leukemia. Generally, when this disease has pre-leukemic features it may include hypogranular neutrophils which is one is a feature of neutrophil dysplasia commonly observed in myelodysplastic syndromes.
2 degrees Fahrenheit and ~ 1 degree Celsius
A: an ecosystems organisms become larger as succession
Answer:
Citrate Synthase facilitates the formation of citrate by deprotonating Acetyl CoA and by protonating the carbonyl oxygen of oxaloacetate
Explanation:
Citrate synthase is a key enzyme in the citric acid cycle that functions to catalyze the formation of citrate from oxaloacetate and acetyl-CoA: acetyl-CoA + oxaloacetate + H2O >> citrate + CoA-SH (Coenzyme A ). This enzyme contains three amino acids at its active site that work together to catalyze the conversion of acetyl-CoA and oxaloacetate into citrate. This active site acts by abstracting (deprotonating) a proton from the alpha carbon of Acetyl CoA which serves as the nucleophile. Subsequently, the active site of the enzyme also protonates the carbonyl oxygen of oxaloacetate, which then suffers nucleophilic attack and thereby facilitating nucleophilic substitution reaction.
