To summarize, food intake is influenced by metabolic activity in hypothalamic neurons and elsewhere; by hormones that signal the body's fat content to the brain; and by other homeostatic-need situations such as low blood glucose. All of these represent instances of negative feedback.
Literally frostbite is the term that is used to describe an area of tissue with that has lost the ability to function due to not having much blood flow due to to a extreme low in temperature. If you begin rubbing a frostbitten section you could of course exaggerate the severity of the wound by breaking the fragile area and forming wounds to which bacteria enter. Additionally you could start influencing blood flow into the area which could then start the process of gangrene (decay), which could bring toxic byproduct of the decay into the body, which could begin shutting down your body starting from the kidneys... A common disease from something like this is rhabdomylosis.
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Having a diabetes pill would impact the world so much. So many people suffer from diabetes, both type 1 and type 2. As a person that has diabetes I have gone into 2 diabetic comas and almost died both times. Yeah there is insulin that diabetics take but when diabetics take to much they go low, but when diabetics don't take enough they go high. So, having a diabetic pill would save so many lives . Having a diabetic pill will also save so many friends and family from the pain of a losing a loved one to diabetes.
