Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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The sickle form of the hemoglobin gene is created when an adenine nucleotide is changed to a thymine. ... That single amino acid replacement in the -globin protein alters the shape and the chemistry of the hemoglobin molecule, causing it to polymerize and distort the red blood cell into the sickle shape.
Answer:
EXERCISE
Explanation:
In an experiment, the independent variable is the variable that the experimenter changes or manipulates in order to bring about a measurable outcome.
In this case, an experiment is carried out to test the hypothesis that "exercise will affect the number of times a person can squeeze a clothespin in a certain amount of time". The experiment contained two groups (one group sits quietly before squeezing a clothespin as many times as possible and the other does 25 JUMPING JACKS before squeezing a clothespin as many times as possible).
The independent variable is the EXERCISE (jumping jacks) that was changed for each group in the experiment.
The correct answer is A.
Animal cells do not have a cell wall.
A cell wall is the rigid, outermost covering of plant cells and is made up of cellulose. It is absent in animal cells. The cell wall is visible under a light microscope.
Animal cells are instead covered by a cell membrane. It is made up of lipids, proteins, and small amounts carbohydrates. It is a thin and delicate structure that can only be seen using an electron microscope.
