<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
The molecule which is the final electron acceptor for electrons from photosystem I is (d) NADP⁺.
Photosystem I is the protein complex involved in the process of photosynthesis. It captures the light energy to mediate the transfer of electrons from a series of electron transporters. It is involved in non-cyclic as well as cyclic photophosphorylation.
NADP⁺ is the Nicotinamide Adenine Dinucleotide Phosphate. It acts as a coenzyme. It is an important constituent in various anabolic reactions like Calvin cycle, lipid and nucleic acid syntheses, etc. The oxidized form of NADP⁺ is NADPH. It is present in organisms of almost all kinds.
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Answer:
<em>The correct option is B) as the light colored moths were seen and eaten, the allele for dark colour became more prevalent in the population.</em>
Explanation:
The process of natural selection tends to favour those organisms which are better adapted to live in an environment. Evolution changes the allele frequencies of a population over time depending on the traits favoured by natural selection.
Before the industrial revolution, the colour of the trees was lighter and hence, the light coloured moths were better adapted to such environments as they could hide from predation. After the industrial revolution, the colour of the woods of trees became darker. The light coloured moths were no more able to hide from their predators and hence their population declined.
Answer:
C. Aldosterone increases sodium reabsorption by increasing the number of Na+-K+ ATPase pumps in the luminal membrane of the proximal tubule.
Explanation;
- Aldosterone hormone is produced by the adrenal gland and mainly carries out its functions in the kidney.Through the aldosterone hormone the body is able to retain more water for the kidney is able to hold more sodium.
- When the plasma sodium levels decrease and the plasma potassium levels increase the production of aldosterone hormone is stimulated for sodium is needed in the .body to maintain the high water levels in the body.