Answer:
1. Inhibiting IP3 channels, leading to decreased Ca2 in the sarcoplasm and reduced contraction.
2. Increasing the relative activity of MLCP, leading to a decrease in tension.
3. Activating K channels, increasing K leaking out of the cell which hyperpolarizes it and decreases the likelihood of Ca2 entry.
Explanation
In smooth muscle, cyclic AMP (cAMP) mediates relaxation because cAMP inhibits a specific kinase required for myosin light chain protein (MLCP) phosphorylation, thereby triggering contraction in the smooth muscles. It has been shown that cAMP inhibits 1,4,5-trisphosphate (IP3)-dependent calcium ions (Ca 2+) release by activation of the cGMP-dependent protein kinase (PKG). PKG proteins act to modulate Ca2+ oscillations by stimulating sarcoplasmic Ca2+-ATPase membrane proteins, increasing Ca2+ in the sarcoplasmic reticulum stores and Ca2+ efflux from the cells, and activate voltage-gated potassium (K) channels, thereby leading to membrane hyperpolarization and reducing Ca2+ entry through Ca2+ channels.
Answer: D. Hypothesis B is more useful because it suggests a way to test the relationship between heart rate and caffeine intake.
Hypothesis A and B both are suggesting that caffeine intake is related to higher heart rate. But hypothesis B is proving it more certainly by suggesting the affects of caffeine intake on heart rate. As, heart rate of most people will be higher 30 minutes after they drink a cup of coffee is testifying the fact, that higher heart rate is related with caffeine intake.
Therefore, hypothesis B is more useful because it suggests a way to test the relationship between heart rate and caffeine intake.
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