OBJECTIVES: To analyze the occurrence and types of neoplasias that have developed in patients submitted to orthotopic heart transplantation in the Cardiac Transplantation Program of the Paulista School of Medicine, Federal University of São Paulo.
METHODS: The present study presents an observational analysis of 106 patients submitted to orthotopic heart transplantation from November 1986 to September 2002, who survived for more than 30 days after the procedure. The immunosuppressive regimen consisted of triple therapy with cyclosporin A, azathioprine and corticosteroid. Only two patients received, in addition to triple therapy, the addition of orthoclone OKT-3. The mean follow-up period was 61.4 months. (variation from two months to 192 months).
RESULTS: Twenty-three patients (21.3%) developed neoplasias, of which 56.5% had skin neoplasms, 30.1% had solid tumors and 13.4% had post-transplantation lymphoproliferative disease (PTLD). The mean interval between transplantation and the diagnosis of neoplasia was: skin - 54.9 months, solid tumors - 24.8 months and DLPT - 70.3 months.
CONCLUSIONS: The occurrence of malignant neoplasms was relatively common in the analyzed population. Skin cancer prevailed in relation to other neoplasms and solid tumors were more diagnosed than lymphoproliferative diseases in this series of patients.
Answer:
Prepositions.
Explanation:
They express relationships such as space, time, or figurative location.
First waves of industrial revolution nuclear power. Backwash of coming of age of space
Some literary critics believe that a large portion of the tale may have been written before the rest of the Canterbury Tales and that the four most contemporary figures were added at a later point. A likely dating for this hypothetical first draft of the text would be the 1370s, shortly after Chaucer returned from a trip to Italy where he was exposed to Giovanni Boccaccio's Concerning the Falls of Illustrious Men as well as other works such as the Decameron. The tragedy of Bernabò Visconti must have been written after 1385, the date of the protagonist's death. The basic structure for the tale is modeled after the Giovanni Boccaccio's Illustrious Men, while the tale of Ugolino of Pisa is retold from Dante's Inferno
