Answer:
Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney and liver function among United States (U.S.) adolescents. This study aimed to evaluate whether greater fluoride exposure is associated with altered kidney and liver parameters among U.S. youth.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2013–2016). We analyzed data from 1983 and 1742 adolescents who had plasma and water fluoride measures respectively and did not have kidney disease. Fluoride was measured in plasma and household tap water. Kidney parameters included estimated glomerular filtration rate (calculated by the original Schwartz formula), serum uric acid, and the urinary albumin to creatinine ratio. Liver parameters were assessed in serum and included alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, gamma-glutamyl transferase, and albumin. Survey-weighted linear regression examined relationships between fluoride exposure and kidney and liver parameters after covariate adjustment. A Holm-Bonferroni correction accounted for multiple comparisons.
The average age of adolescents was 15.4 years. Median water and plasma fluoride concentrations were 0.48 mg/L and 0.33 μmol/L respectively. A 1 μmol/L increase in plasma fluoride was associated with a 10.36 mL/min/1.73 m2 lower estimated glomerular filtration rate (95% CI: −17.50, −3.22; p = 0.05), a 0.29 mg/dL higher serum uric acid concentration (95% CI: 0.09, 0.50; p = 0.05), and a 1.29 mg/dL lower blood urea nitrogen concentration (95%CI: −1.87, −0.70; p < 0.001). A 1 mg/L increase in water fluoride was associated with a 0.93 mg/dL lower blood urea nitrogen concentration (95% CI: −1.44, −0.42; p = 0.007).
Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents. As the study is cross-sectional, reverse causality cannot be ruled out; therefore, altered kidney and/or liver function may impact bodily fluoride absorption and metabolic processes.
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Igneous rocks are formed when the magma from an erupting volcano eventually cools this rock is extrusive- found on the earth's surface.
Answer: (<u>Note</u>: You will find the image with the highlighted structure in the attached file)
Peyer's patches (aggregated lymphoid nodules)
Explanation:
Peyer's patches are anatomical regions located under the mucosa of the gastrointestinal tract, specifically in the lamina propria of the thin intestine. These patches are nodules or cumulus of lymphatic tissue and other accessory cells, and this is why they represent a huge part of the mucosa´s immunity system.
Peyer's patches belong to the group of lymphoid tissue associated with the intestine, composed of lymphoid follicles distributed along the gastrointestinal tract.
A lymphoid follicle is a cumulus or aggregate of lymphoid cells that do not have a well-defined structure nor organization. In general, these follicles are isolated from each other in the intestine. But in the terminal ileum (The last portion of the thin intestine) they get so close that they might form a plaque. The Peyer´s patches are formed principally by lymphocytes B that synthesize immunoglobulin A, which has an important role in immunity.
