That would be smallpox hopes this helps -T
Answer:
No food for them to eat
Explanation:
Only 60 of 500 colonists survived the period, now known as “the starving time.” Historians have never determined exactly why so many perished, although disease, famine (spurred by the worst drought in 800 years, as climate records indicate), and Indian attacks took their toll.
Answer:
Of the four great battles Alexander fought in the course of his brilliant military career, the Battle of the Granicus, fought in May 334 BC, was the first–and the one in which he came closest to failure and death.
Combatants: Achaemenid Empire; Greece