<span>Testosterone achieves his effect by binding to his androgen receptor (nuclear). Because testosterone is steroid hormone (derived from cholesterol), it has a possibility to free diffuse through the cell membrane. When testosterone binds, the receptor undergoes a structural change which allows it to move into the cell nucleus and dimerize. Receptor dimer than binds directly to the specific sequence of the DNA called hormone response element (HRE) which results in regulation of gene expression.</span>
Testosterone functions inside a cell by binding with a receptor protein that enters the nucleus and activates specific genes. Testosterone is the principle male sex hormones in mammals, birds and other vertebrates. Its effects are exerted by; Testosterone can activate the androgen receptor itself or after conversion to 5 alpha dihydrotestosterone by the enzyme 5 alpha reductase.
Because the enzyme has changed its shape it has become unreversably denatured the active site does not match the substrate thefore their will be no reaction
<span>The ratio of both groups would stay the same. Reason being the ratio in urine osmolality is divided by blood osmolality. The mice with no access to water the ratio of urine osmolality to blood osmolality are 14:7 while for mice with unlimited access to water the ratio of urine osmolality to blood osmolality is 1:4. In conclusion, the mice with no access to water produce highly concentrated urine.</span>