Order the following statements to illustrate the correct cascade of events that occurs after ligand binding of G-protein coupled
receptor (heptahelical receptor). 1. Degradation of cAMP by phosphodiesterase 2. Dissociation of Gβ and Gγ subunits 3. G protein exchanges GDP for GTP in the G-αs subunit 4. Activation of adenylyl cyclase (effector E) to generate cAMP