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Ne4ueva [31]
3 years ago
7

Which enzyme functions to prevent supercoiling of the DNA molecule during replication?

Biology
2 answers:
Zepler [3.9K]3 years ago
5 0

Answer:

Topoisomerase

Explanation:

I just did it on USATESTPREP

melamori03 [73]3 years ago
3 0

Answer:

The enzyme Topoisomerase functions to prevent super-coiling of the  DNA molecule during replication.

Explanation:

  • During replication, topoisomerases are required to relieve the positive supercoiling that arises from DNA unwiding mediated by Helicases.
  • A DNA topoisomerase is a nuclease that breaks a phosphodiester bond in a DNA strand.
  • All topoiomereases are classified as  Topoisomerase I and Topoisomerase II  depending on whether they cleave one or two strands respectively.
  • Topoisomerase I do not use ATP as a source of energy, the reaction is powered by energy stored in super-coiled DNA.
  • Topoisomerase II also do not require external energy but it utilizes ATP hydrolysis to drive conformation changes in the protein during reaction cycle.

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