It would be Plaque because plaque is <span>a sticky deposit on teeth in which bacteria proliferate.
which we know bacteria is </span><span>Bacteria constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a number of shapes, ranging from spheres to rods and spirals!</span>
Answer by JKismyhusbandbae: Repeated drug use may lead to drug tolerance which occurs when a user requires larger amounts of the drug to achieve the desired effect.