In the mutant hemoglobin known as HB Providence, an asparagine residue in the β-chain replaces Lys-82. In normal hemoglobin, Lys
-82 projects into the central cavity of the hemoglobin molecule. Predict the effect of the Lys → Asn mutation on the affinity of allosteric modifiers (relative to normal Hb e.g. HbA) and describe the effect the mutation would have on the function (oxygen binding) of HB Providence.
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