Answer:
The answer is reciprocal chromosomal translocation
Explanation:
The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.
Is there a data image if there is tell me so I can help you
Answer: To know if a document is a primary source, check to see when the document is published, if it is an autobiography of a person, a diary, a letter, or the documents happen at the time of the event.
The competition between two organisms can be seen if there is only 1 source of food or habitat space and they're competing against each other for the food or habitat.
There is cooperation between two organisms if they are helping each other with resources or alarming each other if there is danger.
Predation between two organisms happen when one organism hunts the other organism for food.
Answer:
The axial skeleton is composed of the bones of the skull, ossicles of the ear, hyoid bone, vertebral column, and ribcage.
Explanation:
brainliest
