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The pluripotent, undifferentiated cells in the bone marrow that give rise to the formed elements are called stem cells.
Pluripotent stem cells have the ability to undergo self-renewal and to give rise to all cells of the tissues of the body. However, this definition has been recently complicated by the existence of distinct cellular states that display these features.
There are two types of pluripotent stem cells :
- Embryonic stem cells (ESCs)
- Induced pluripotent stem cells
Embryonic stem cells are derived from the inner cell mass (ICM) of pre-implantation embryos and can be indefinitely maintained and expanded in the pluripotent state in vitro. Pluripotent stem cells can also be obtained by inducing dedifferentiation of adult somatic cells through a recently developed in vitro technology, known as cell reprogramming.
Similarly to Embryonic stem cells , Induced pluripotent stem cells can be expanded indefinitely and they are capable to differentiate in all the derivatives of the three germ layers.
Another intriguing features of being pluripotent is its reliance on gene expression heterogeneity.
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Answer: Large molecules and wastes move through the membrane through forms of active transport- endocytosis and exocytosis.
Explanation:
Molecules are moved across the cell membrane via different mechanisms like diffusion, facilitated diffusion and passive transport; however, some very large molecules require specialized types of active transport to cross over- these are endocytosis and exocytosis.
During endocytosis large molecules cells and cell fragments moved across the plasma membrane through a process of <em>invagination;</em> piece of the external cell membrane falls into itself and forms a small pocket that surrounds the target molecule this breaks off from the membrane to form an intracellular vesicle. Different methods of endocytosis such as <em>phagocytosis, pinocytosis </em>and receptor-mediated <em>endocytosis</em>, take in cells, water and targeted substances respectively.
Like endocytosis, the particles (signal proteins, neurotransmitters and waste material) are surrounded by a phospholipid membrane. However, in exocytosis, this membrane is formed in the cytoplasm, and merges with the plasma membrane’s interior in a process <em>opposite to </em>endocytosis; material is removed from the cell and exported into the cell’s exterior called the extracellular space.
An action potential involves potassium ions moving <u>outside </u>the cell and sodium ions moving <u>inside </u>the cell.
<h3>how does it action potential work?</h3>
Neurons have a negative concentration gradient most of the time, meaning there are more positively charged ions outside than inside the cell. This regular state of a negative concentration gradient is called resting membrane potential. During the resting membrane potential there are:
- more sodium ions outside than inside the neuron
- more potassium ions inside than outside the neuron
The concentration of ions isn’t static though! Ions are flowing in and out of the neuron constantly as the ions try to equalize their concentrations. The cell however maintains a fairly consistent negative concentration gradient (between -40 to -90 millivolts). How?
- The neuron cell membrane is super permeable to potassium ions, and so lots of potassium leaks out of the neuron through potassium leakage channels (holes in the cell wall).
- The neuron cell membrane is partially permeable to sodium ions, so sodium atoms slowly leak into the neuron through sodium leakage channels.
- The cell wants to maintain a negative resting membrane potential, so it has a pump that pumps potassium back into the cell and pumps sodium out of the cell at the same time.
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