Answer:
The answer is reciprocal chromosomal translocation
Explanation:
The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.
D) long chains of amino acids used for building, repair and maintenance
Human beings can only see a small fraction of the wavelengths that make up the electromagnetic spectrum. <em>;)</em>
Top-down effects imply control through predation, including fishery, while
bottom-up effects imply control through food abundance, often thought to be driven by climate or nutrient load.
<h3>What is Top down regulation ?</h3>
The top-down effect refers to a higher trophic level influences the community structure of a lower trophic level through predation.
<h3>What is Bottom up regulation ?</h3>
The bottom-up effect means that a lower trophic level in the biological network affects the community structure of higher trophic levels by means of resource restriction
Learn more about Top down and bottom up regulation here:
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Answer:
K-Pb
Explanation:
because according to the radioactive elements it is because the rock cannot express its feeling buy you can see by it's texture how it feels about your decision
