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kifflom [539]
3 years ago
8

Compare and contrast the contributions of Neel, Pauling, and Ingram to our understanding of the genetic and molecular basis of s

ickle cell disease (SCD).
Biology
1 answer:
taurus [48]3 years ago
7 0

He demonstrated that SCD and sickle cell trait were due to the presence of abnormal 8-globin polypeptides in red blood cells. He demonstrated that the electrophhoretic mobility of B-globin from patients with SCD was different from that of healthy individuals. He demonstrated that both parents of multiple patients with SCD had low levels of sickled red blood cells. He hypothesized that SCD was a recessive trait and that the parents of patients with SCD would be heterozygous carriers. He demonstrated that the difference between B-globin polypeptides in individuals who were healthy and those with SCD is an amino acid substitution. He performed a peptide fingerprint analysis on B-globin from individuals with 84 84 and 89 88, which identified the segment of B-globin that was changed by the BS mutation. James Neel Linus Pauling Vernon Ingram

hope it helps..

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Degeneration of the dopamine-releasing neurons of the ________ is the ultimate cause of Parkinson's disease. Degeneration of the
slavikrds [6]

Answer:

a. substantia nigra

b. substantia nigra (it is repeated)

Explanation:

Parkinson's disease is a neurodegenerative disease that is caused by the death of neurons that release the neurotransmitter dopamine in the <u>substantia nigra</u>, or locus niger, -a region of the brain that regulates brain circuits that give the 'orders' to initiate voluntary movements- .

The lack of this neurotransmitter leads to the occurrence of the main symptoms suffered by patients: decreased movements, muscle stiffness, postural instability and tremor. These failures are generated by the abnormal way in which neurons work in the absence of dopamine through a mechanism that is not known in depth.

It is the second most frequent neurodegenerative disease, after Alzheimer's disease, with a prevalence of 2% in people over 65 years. The characteristic symptoms of stiffness, bradykinesia and tremor are associated with losses of neurons in the substantia nigra and dopamine depletion in the striatum. There are large cytoplasmic inclusions, called Lewy bodies, which are the pathological mark of the disease and appear predominantly in neurons that contain melanin of the nigra substance. Genetic studies in a subgroup of families with Parkinson's disease with autosomal dominant inheritance found a locus on chromosome 4q-21 23 and a mutation in the gene that encodes a synaptic protein, α-synuclein.

7 0
3 years ago
What is the term for the diffusion of water across a semipermeable membrane?
AveGali [126]

The term used for the diffusion of water across a semipermeable membrane is called Osmosis

5 0
3 years ago
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bulgar [2K]
I believe the answer is A!
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Linked genes are genes that Select one: a. assort independently. b. segregate equally in the gametes during meiosis. c. always c
nexus9112 [7]

Answer:

d. are found on the same chromosome

Explanation:

Linked genes are genes that <em>sit close together on the same chromosome,</em> this closeness makes higher the probability to inherit them together, meaning they won't follow Mendelian inheritance. Considering this information we can conclude that the correct answer is d. are found on the same chromosome.

I hope you find this information useful and interesting! Good luck!

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Which option below represents the best way to paraphrase and cite the source of the information from the first two sentences in
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