Many of the neurodegenerative disorders are the result of the flaws in the folding of the protein, which comprises Parkinson, Alzheimer, prion, and Huntington diseases. Once the protein specific to disease misfolds, it can then produce toxic masses that gather in the brain, resulting in cell death, neuronal dysfunction, and clinical symptoms.
As misfolding of proteins and the gathering of masses are the most upstream occurrences in the pathological cascade, thus, stabilizing or rescuing the native conformations of proteins is a better therapeutic approach.
In the present times, small molecules called chaperones have been demonstrated to be effective in minimizing the levels of misfolded proteins, thus reducing the gathering of masses and their downstream pathological outcomes. Chaperones are categorized as pharmacological, molecular, or chemical.
Answer:
motor end plate membrane potential,
it applies all or none law. either it generates full threshold level potential or it does not produce any potential. after being released from the presynaptic neuron, ACh binds with the receptor of the postsynaptic neuron, which leads to the depolarization of the cell membrane by the increased transportation of Na and K. then, MEPP leads to increased depolarization in the postsynaptic membrane which is also known as end-plate potential.
A. is the incorrect statement.
Answer:
The type of wire
Explanation:
The type of wire is the change in this experiment
Answer:
La célula procariota se considera la antecesora de la eucariota por lo tanto comparten varias características. Ambas poseen membrana plasmática, citoplasma, citosol, ADN y ribosomas.