Question

gHow would an inhibitor of cAMP phosphodiesterase affect glucose mobilization in muscle? It would reduce cAMP levels and inhibit glucose mobilization. It would maintain high cAMP levels and elevate glucose mobilization. It would increase AMP concentration, thereby increasing glucose mobilization. It would increase cAMP levels, which would inhibit glucose mobilization.

Answer 1

cAMP and glucose mobilization

Explanation:

It would maintain high cAMP level and elevate glucose mobilization

• Phosphodiesterase is an effector enzyme which degrades secondary messenger cAMP(cyclic adenosine monophosphate)
• Here in this case an inhibitor is inhibiting the phosphodiesterase therefore cAMP level will increase
• As cAMP level rise it activates a protein called protein kinase A which phosphorylates phosphorylase kinase and activates it
• Phosphorylase kinase becomes active that phosphorylates glycogen phosphorylase and makes it active,glycogen phosphorylase catalyse breakdown of glycogen(in liver and muscle cells)
• In liver cells breakdown of glycogen occurs and glucose 1 phosphate gets converted into glucose and supplied to whole body through blood