<span>Rhabdomyolysis constitutes a common cause of acute renal failure and presents paramount interest. A large variety of causes with different pathogenetic mechanisms can involve skeletal muscles resulting in rhabdomyolysis with or without acute renal failure. Crush syndrome, one of the most common causes of rhabdomyolysis presents increased clinical interest, particularly in areas often involved by earthquakes, such as Greece and Turkey. Drug abusers are another sensitive group of young patients prone to rhabdomyolysis, which attracts the clinical interest of a variety of medical specialties.
We herein review the evidence extracted from updated literature concerning the data related to pathogenetic mechanisms and pathophysiology as well as the management of this interesting syndrome.
Keywords: Rhabdomyolysis, acute renal failure, myoglobin, crush syndrome
The first case of the crush syndrome, which constitutes one of the main causes of rhabdomyolysis, was reported in Sicily in 1908, after an earthquake1,2. In 1930, in the Baltic area, an epidemic of myoglobinuria was observed due to consumption of contaminated fish. Interest in rhabdomyolysis and crash syndrome was stimulated during the World War II particularly after the bombing in London, where the victims developed acute renal failure and myoglobinuria1.
Rhabdomyolysis is a rupture (lysis) of skeletal muscles due to drugs, toxins, inherited disorders, infections, trauma and compression3. Lysis of muscle cells releases toxic intracellular components in the systemic circulation which leads to electrolyte disturbances, hypovolemia, metabolic acidocis, coagulation defects and acute renal failure due to myoglobin4.
The skeletal muscle consists of cylindrical myofibrils, which contain variant structural and contraction proteins. Actin and myosin, arranged in thin and thick filaments respectively, form the repeated functional units of contraction, the sarcomeres5. The sarcoplasmic reticulum constitutes an important cellular calcium storage. It is structurally connected to the t-tubules, that are formed by invaginations of the muscle cell plasma membrane, the sarcelemma, around every fibril (Figure 1). After the sarcelemma depolarization, the stimulation arrives, through the t-tubules junctions, at the sarcoplasmic reticulum, inducing the calcium ions release and triggering muscle contraction6.</span>
D. Gene splicing. They remove specific genes in order to create a transgenic organism.
Answer:
Please find the explanation of transcription and translation below using the key words.
Explanation:
Transcription is the process whereby a gene in a DNA template is used to synthesize a messenger RNA (mRNA) molecule in the nucleus of the cell. This process of transcription occurs with the aid of an enzyme called RNA POLYMERASE, which adds the nucleotides complementary to the one it reads in the gene to the growing mRNA strand.
Translation, on the other hand, is the second process of gene expression involving the synthesis of proteins from the mRNA sequence. This process occurs in the RIBOSOME where a group of three nucleotides in the mRNA called CODON is read by another group of complementary nucleotide in the transfer RNA (tRNA) called ANTICODON. The tRNA then carries amino acids corresponding to what is read in the codon to the growing polypeptide chain.
If a dihybrid F1 plant, self-fertilizes, the F2 progeny will have two types of phenotypes. One would be the dominant trait phenotype for both the alleles, which would be possessed by 3/4th of the population.
Other would be recessive trait phenotype for both the alleles, which would be possessed by 1/4th of the population.
One fourth of the population would be true-breeding for the dominant traits.
Half of the population would be heterozygous for both traits and would have dominant phenotype
Rest one-fourth population would be homozygous for both recessive traits
