48 because the formula for work is w=f•d so when you plug f and d in its 12 times 4, giving you 48.
Answer:
Skid
Explanation:
A skid is an automobile handling condition in which one or more tires are slipping relative to the road. So when trying to recover from a skid, do not brake and keep your eyes in the direction you want to go and you will automatically steer there because the overall handling of the vehicle is affected by the skid at that particular moment.
All the steps of GPCR signaling would be prevented in the presence of a beta-blocker drug.
<h3>What is Beta-blocker?</h3>
Beta-blocker may be defined as a kind of medication that chokes the activity of substances, such as adrenaline, on nerve cells and provokes blood vessels to relax and dilate.
Adrenergic receptors choke the attachment of catecholamine that is epinephrine to the G-protein. G-protein activates adenylyl cyclase which in turn activates protein kinase A.
But when the beta-blocker drug is subjected to this pathway, it blocks the attachment of the hormone to their receptors, hence none of the pathway or steps would be carried forward. This is because signaling is not initiated.
Therefore, all the steps of GPCR signaling would be prevented in the presence of a beta-blocker drug.
To learn more about GPCR signaling, refer to the link:
brainly.com/question/9882354
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The lock-and-key mechanism was first proposed by Emil Fischer which described as the enzymatic reactions whereby an enzyme with a single substrate binds temporarily to form a substrate complex. Just like a lock and key the enzyme as the lock and the substrate as the key is said to fit together
