An enzyme is a protein and when that enzyme is denatured because of high level or lower level of pH it therefore cannot carry out its function and it is best Carried out at the pH of seven
1. NaOH dissociates in water.
2. NaOH is a base.
That's what I get from that. NaOH must dissociate in water to raise the concentration of anything, and it must be basic, otherwise it would raise the hydronium concentration or nothing at all.
They can either be protons (positive) or electrons (negative)