Answer:
Because you could be wrong.
Explanation:
if you mess up one thing it can mess up the entire project or experiment.
<span>Unidirectional flow in the heart is ensured because the heart contains valves that prevent backflow.
These valves keep the flow of the heart going in one direction (hence the name "unidirectional").</span>
Respuesta: Energía eólica.
Explicación: La energía eólica o las cosas que utilizan energía eólica, como las turbinas eólicas, no liberan emisiones que puedan contaminar el aire o el agua. Por tanto, una fuente de energía no contaminante.
Espero que esto ayude, buena suerte! :)
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
#SPJ4
Explanation:
Eukaryotic cells are more complex than prokaryotes, and the DNA is linear and found within a nucleus. Eukaryotic cells boast their own personal "power plants", called mitochondria.
hope it helps!
