Development of cognitive instruments for use in clinical trials of antidementia drugs:Alzheimer's Disease Assessment Scale (ADAS).
What is Alzheimer's Disease Cooperative Study?
The Alzheimer's Disease Cooperative Study (ADCS) cognitive assessment procedure was created to investigate the validity and reliability of cognitive assessment tools that could be useful additions to the Alzheimer's Disease Assessment Scale (ADAS) or other short batteries used in antidementia medication studies. Patients with mild to moderate AD and elderly individuals with normal cognitive function underwent a battery of five tests at least three times over the course of a year as part of an overall ADCS protocol to create new instruments for use in clinical trials of treatments for Alzheimer's disease (AD). The main result of this inquiry was the discovery of certain prospective additions to the current ADAS that broaden the scope of the cognitive domains and symptom severity levels addressed.
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Explanation:
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Answer:
The ICD-10-CM code for acute cystitis with hematuria is <u>N30.01</u>
Explanation:
ICD-10 refers to the medical classification list and codes of various diseases and the related health problems, given by the World Health Organization. It contains codes for the various symptoms and signs, diseases, social circumstance, external cause of diseases and injuries, complaints and abnormal findings.
<u>The ICD-10-CM code for acute cystitis with hematuria is </u><u>N30.01</u><u>.</u>
Pernicious anemia produces red blood cells that are <u>large</u> and<u> vitamin B12</u> deficiency contributes to pernicious anemia.
Explanation:
When there is a lack of intrinsic factor, secreted in the parietal cells of the gastric mucosa or the stomach lining, vitamin B12 absorption from the stomach is affected.
Vitamin B12 is one of the key factors responsible for normal synthesis and maturation of fully functional red blood cells (RBCs).
The main function of the RBCs is to carry oxygen through hemoglobin to all parts of the body. In order to transport oxygen, the RBCs must be mature with normal shape (concave center and circular shape) and size.
When there is a lack of vitamin B12, the RBCs are not matured and immature, megaloblastic, large, irregularly-shaped red blood cells are formed and circulate in the blood. This also leads to macrocytosis of RBCs.
These cannot function as normal mature blood cells because of the irregular shape and cannot carry hemoglobin to transport oxygen.
